Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older AdultsReport as inadecuate




Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults - Download this document for free, or read online. Document in PDF available to download.

Background

Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults.

Methods

Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects age 55–85 years randomly selected from the Hunter Community Study.

Results

Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78–1.33 µmol-L. Concentrations were not affected by gender P = 0.41 or by presence of chronic medical conditions P = 0.15. By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 90% CI 0.31–0.44 to 3.08 90% CI 2.45–3.76 µmol-L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age rpartial = −0.15; P = 0.0018 and with glutamylcysteine concentrations rpartial = −0.13; P = 0.0063.

Conclusions

A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.



Author: Salvatore Sotgia , Angelo Zinellu, Arduino A. Mangoni, Gianfranco Pintus, John Attia, Ciriaco Carru, Mark McEvoy

Source: http://plos.srce.hr/



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