Insulin Resistance Is an Independent Determinate of ED in Young Adult MenReport as inadecuate




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Background

Insulin resistance IR triggers endothelial dysfunction, which contributes to erectile dysfunction ED and cardiovascular disease.

Aim

To evaluate whether IR was related to ED in young adult patients.

Methods

A total of 283 consecutive men complaining of ED at least six months were enrolled, with a full medical history, physical examination, and laboratory tests collected. Quantitative Insulin Sensitivity Check Index QUICKI was used to determine IR. The severity of ED was assessed by IIEF-5 questionnaire. Endothelial function was assessed by ultrasonographic examination of brachial artery flow mediated dilation FMD.

Results

IR was detected in 52% patients. Subjects with IR had significant higher total cholesterol, triglycerides, low density lipoprotein-cholesterol LDL-c, glycated haemoglobin HBA1c, high sensitivity C-reactive protein hs-CRP and body mass index BMI, but showed significant lower IIEF-5 score, FMD%, high density lipoprotein -cholesterol HDL-c, testosterone, sex hormone binding globulin SHBG levels than patients without IR. Multiple regression analysis showed QUICKI and testosterone were independent predictors of IIEF-5 score. Furthermore, the incidence of IR was correlated with the severity of ED.

Conclusions

Compared with other CVFs, IR was found as the most prevalent in our subjects. Besides, IR was independently associated with ED and its severity, suggesting an adverse effect of insulin resistance on erectile function.



Author: Shengfu Chen , Rongpei Wu , Yanping Huang , Fufu Zheng, Yangbin Ou, Xiangan Tu, Yadong Zhang, Yong Gao, Xin Chen, Tao Zheng, Qiyu

Source: http://plos.srce.hr/



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