Development of a Phase-amplitude Coupling Toolbox for Assessing Changes in Cross-frequency Coupling Due to Deep Brain Stimulation Therapies for Treatment Resistant DepressionReport as inadecuate


Development of a Phase-amplitude Coupling Toolbox for Assessing Changes in Cross-frequency Coupling Due to Deep Brain Stimulation Therapies for Treatment Resistant Depression


Development of a Phase-amplitude Coupling Toolbox for Assessing Changes in Cross-frequency Coupling Due to Deep Brain Stimulation Therapies for Treatment Resistant Depression - Download this document for free, or read online. Document in PDF available to download.

Phase-amplitude coupling PAC is theorized to play a fundamental physiological role in neuronal oscillations of the brain. This work contends that changes in PAC due to deep brain stimulation DBS in treatment-resistant depression TRD can account for the palliative effects observed in TRD patients. Part of this work compares the efficacy of six metrics for PAC based on their application to synthetic signals: the Kullback-Leibler based modulation index KL-MI, the heights ratio HR, the general linear model GLM, the phase locking value PLV, the mean vector length normalized by principal component analysis PCA, and the coherence value CV. GLM gives the smallest region of detected coupling in the comodulograms, evades bimodality artifacts arising from the continuous wavelet transform CWT in this region of interest, and provides the greatest visual contrast. After an initial stage of validation and characterization of each metric, these metrics would then be applied to recorded local field potentials LFP before and after DBS to assess PAC. The goal of this work is to present a toolbox of metrics that are characterized on synthetic signals which would serve as a benchmark to clinicians for application to patient data.



Undergraduate Research Option Theses - Department of Biomedical Engineering Undergraduate Research Option Theses -



Author: Ali, Rehman - -

Source: https://smartech.gatech.edu/







Related documents