Is Serum Zinc Associated with Pancreatic Beta Cell Function and Insulin Sensitivity in Pre-Diabetic and Normal Individuals Findings from the Hunter Community StudyReport as inadecuate




Is Serum Zinc Associated with Pancreatic Beta Cell Function and Insulin Sensitivity in Pre-Diabetic and Normal Individuals Findings from the Hunter Community Study - Download this document for free, or read online. Document in PDF available to download.

Aim

To determine if there is a difference in serum zinc concentration between normoglycaemic, pre-diabetic and type-2 diabetic groups and if this is associated with pancreatic beta cell function and insulin sensitivity in the former 2 groups.

Method

Cross sectional study of a random sample of older community-dwelling men and women in Newcastle, New South Wales, Australia. Beta cell function, insulin sensitivity and insulin resistance were calculated for normoglycaemic and prediabetes participants using the Homeostasis Model Assessment HOMA-2 calculator.

Result

A total of 452 participants were recruited for this study. Approximately 33% N = 149 had diabetes, 33% N = 151 had prediabetes and 34% N = 152 were normoglycaemic. Homeostasis Model Assessment HOMA parameters were found to be significantly different between normoglycaemic and prediabetes groups p<0.001. In adjusted linear regression, higher serum zinc concentration was associated with increased insulin sensitivity p = 0.01 in the prediabetic group. There was also a significant association between smoking and worse insulin sensitivity.

Conclusion

Higher serum zinc concentration is associated with increased insulin sensitivity. Longitudinal studies are required to determine if low serum zinc concentration plays a role in progression from pre-diabetes to diabetes.



Author: Khanrin P. Vashum , Mark McEvoy, Abul Hasnat Milton, Md. Rafiqul Islam, Stephen Hancock, John Attia

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents