The Effect of Luteal-Phase Support with Triptrolin Administration on Implantation and Clinical Pregnancy Rate in Assisted Reproductive TechnologyReport as inadecuate




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Background: Luteal phase support with GnRH agonist administration has been shown to be effective in improving the outcome of assisted reproductive technology. The goal of this study was to evaluate the effect of single dose Triptrolin a GnRH agonist on the probability of the clinical pregnancy rate following embryo transfer ET in assisted reproductive techniques ART. Methods: In this double blinded randomized clinical trial, 340 infertile women who were candidates for intra-cytoplasmic sperm injection ICSI were randomly assigned to receive GnRH agonist Triptrolin in the luteal phase or placebo. In the intervention group, 0.1 mg Triptrolin was injected subcutaneously, while the control group received normal saline. The clinical pregnancy and implantation rate were compared between the two groups using chi-2 and t-test. P-values less than 0.05 were considered significant. The registration number of this clinical trial is IRCT 2014030916912N1. Results: Administration of 0.1 mg Triptrolin on day 6 after oocyte pick up showed no superiority over placebo in implantation 16.9% - 14%, P = 0.40 and clinical pregnancy rates 32% - 29%, P = 0.66, but the rate of clinical pregnancy was higher in women who were below 27 years of age and those with PCO. Conclusion: Administration of Triptrolin was not superior to placebo for luteal phase support.

KEYWORDS

Luteal Phase Support, GnRH Agonist, Implantation Rate, Clinical Pregnancy

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Aghahosseini, M. , Alleyassin, A. , Safdarian, L. , Gharahjeh, S. , Saeidi, H. , Sarvi, F. , Hosseini, S. , Mohammadi, N. , Roshandel, G. and Gharajeh, J. 2017 The Effect of Luteal-Phase Support with Triptrolin Administration on Implantation and Clinical Pregnancy Rate in Assisted Reproductive Technology. Open Journal of Obstetrics and Gynecology, 7, 571-580. doi: 10.4236-ojog.2017.75060.





Author: Marzieh Aghahosseini1, Ashraf Alleyassin1, Leili Safdarian1, Saeedeh Gharahjeh1*, Hojat Saeidi1, Fatemeh Sarvi1, Sedigheh Hossein

Source: http://www.scirp.org/



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