Four Genetic Polymorphisms of Lymphotoxin-Alpha Gene and Cancer Risk: A Systematic Review and Meta-AnalysisReport as inadecuate




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Lymphotoxin-alpha LTA is a pro-inflammatory cytokine that plays an important role in the inflammatory and immunologic response. Numerous studies have shown LTA polymorphisms as risk factors for cancers, but the results remain inconclusive. The goal of the present meta-analyses is to establish the associations between cancers and four LTA variants rs1041981, rs2239704, rs2229094 and rs746868. A total of 30 case-control studies involving 58,649 participants were included in the current meta-analyses. Our results showed significant associations with increased cancer risk for rs1041981 odd ratio OR = 1.15, 99% confidential interval CI = 1.07-1.25, P < 0.0001, I2 = 12.2%, rs2239704 OR = 1.08, 99% CI = 1.01-1.16, P = 0.021, I2 = 0.0% and rs2229094 OR = 1.28, 99% CI = 1.09-1.50, P = 0.003, I2 = 0.0%. No evidence was found for the association between rs746868 and cancer risk OR = 1.01, 99% CI = 0.93-1.10, P = 0.771, I2 = 0.0%. Subgroup meta-analysis suggested that rs2239704 was likely to increase the risk of hematological malignancy OR = 1.10, 99% CI = 1.01–1.20, P = 0.023, I2 = 0.0%, and rs2229094 was specific for the increased risk of adenocarcinoma OR = 1.33, 99% CI = 1.11-1.59, P = 0.002, I2 = 0.0%. In conclusion, our meta-analyses suggested that the LTA rs1041981, rs2239704 and rs2229094 polymorphisms contributed to the increased risk of cancers. Future functional studies were needed to clarify the mechanistic roles of the three variants in the cancer risk.



Author: Yi Huang , Xi Yu , Lingyan Wang , Shengjun Zhou, Jie Sun, Nan Feng, Sheng Nie, Jingmi Wu, Feng Gao, Bing Fei, Jianyong Wang, Zhiq

Source: http://plos.srce.hr/



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