Fc-Epsilon Receptor CD23 Expressing Follicular Dendritic Cells as a Main Prognostic Factor in Follicular LymphomaReport as inadecuate




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Fc-epsilon receptor CD23-expressing follicular dendritic cells is a main prognostic factor in follicular lymphoma. Falaleeva N. A., Osmanov E. A., Tupitsyn N. N. Federal State Budgetary Institute N. N. Blokhin Russian Cancer Research Center, Health Ministry of Russian Federation, Moscow, Russia SUMMARY Follicular dendritic cells, expressing FcεRII or CD23 FcεRIIFDCs as a component of non-tumor environment have been studied in 232 follicular lymphoma FL patients. FcεRIIFDCs were found in 87.5% of follicular lymphoma cases and were associated with a nodular pattern of tumor growth p = 0.000, but not the cytological grade of lymphoma. There were no associations of FcεRIIFDC with clinical prognostic factors FLIPI indices or with bone marrow involvement in FL patients by histology. The presence of FcεRIIFDCs in tumor tissue was an independent prognostic factor according to treatment results, i.e. frequency of CR, duration of OS and PFS. Bone marrow involvement significantly worsened the prognosis in FcεRIIFDC-positive group of patients. We suggest a new prognostic index FDC-IP that allows biochemical identification of the following patient groups: FcεRIIFDC-positive patients without bone marrow involvement good prognosis, FcεRIIF-DC-positive patients with bone marrow involvement intermediate prognosis, FcεRIIFDC-negative patients poor prognosis. These 3 groups significantly differ p = 0.000 both in OS and in PFS. This is the first evidence of the possibility to assess tumor behavior and treatment results in FL according to lymphoma biochemical and other than clinical parameters.

KEYWORDS

Follicular Lymphoma, CD23-Positive Follicular Dendritic Cells, Prognosis

Cite this paper

Falaleeva, N. , Osmanov, E. and Tupitsyn, N. 2017 Fc-Epsilon Receptor CD23 Expressing Follicular Dendritic Cells as a Main Prognostic Factor in Follicular Lymphoma. Advances in Biological Chemistry, 7, 107-121. doi: 10.4236-abc.2017.72007.





Author: Natalia A. Falaleeva, Eugeny A. Osmanov, Nikolay N. Tupitsyn*

Source: http://www.scirp.org/



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