Residue Study for a Standardized Macleaya cordata Extract in Growing-Finishing SwineReport as inadecuate




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The aim of this study was to assess the effects ofSangrovit®, a standardized preparation of Macleaya cordata extract MCE, on thehealth status and retained residues in growing-finishing swine. A total oftwelve growing-finishing swine n = 6for each group were randomly divided into two groups and fed either a controlfeed or the control feed supplemented with 100 mg-kg Sangrovit®3.5 mg-kg MCE for 28 days. The parameters for growth and health status wereevaluated during the trial and after which the animals were slaughtered.Residual levels of MCE in swine organs and tissues were determined by measuringsanguinarine and chelerythrine levels by LC-MS-MS. The results showed nostatistically significant differences in live weight, feed intake and averagedaily gain between the treatment and control groups. The feed supplemented with100 mg-kg Sangrovit® was well tolerated by theswine, with no adverse effects noted during the feeding period or in thenecropsy results. Residue analysis indicated that levels of sanguinarine orchelerythrine were under the limit of detection in all the examined tissues andorgans from the treated swine. This study demonstrates that Sangrovit®,a standardized preparation of MCE when fed to growing-finishing swine for 28days, at the level of 100 mg-kg in feed, does not result in sanguinarine orchelerythrine residues in the organs or tissues.

KEYWORDS

Macleaya cordata Extract, Swine, Sanguinarine, Tolerability, Residues

Cite this paper

Zhao, L. , Matulka, R. , von Alvensleben, S. and Morlacchini, M. 2017 Residue Study for a Standardized Macleaya cordata Extract in Growing-Finishing Swine. Open Journal of Animal Sciences, 7, 93-104. doi: 10.4236-ojas.2017.72008.





Author: Lu Zhao1*, Ray A. Matulka1, Sophie von Alvensleben2, Mauro Morlacchini3

Source: http://www.scirp.org/



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