Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus ErythematosusReport as inadecuate




Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus - Download this document for free, or read online. Document in PDF available to download.

Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus SLE. This study’s goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2D+CD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. However, juvenile-onset SLE patient plasma and matched urine samples were positive by ELISA for the soluble form of the NKG2D ligands MICA and MICB, suggesting that kidney and-or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D+CD4 T cell population expansions in this disease.

KEYWORDS

NKG2D Ligands, NKG2D+ CD4 T Cells, Juvenile-Onset Systemic Lupus Erythematosus, B Cells, Monocytes

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Hamada, S. , Caballero-Benitez, A. , Duran, K. , Stevens, A. , Spies, T. and Groh, V. 2017 Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D+CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus. Open Journal of Immunology, 7, 1-17. doi: 10.4236-oji.2017.71001.





Author: Satoru Hamada1,2, Andrea Caballero-Benitez1, Kate L. Duran1, Anne M. Stevens3,4, Thomas Spies1, Veronika Groh1*

Source: http://www.scirp.org/



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