Clinical Implications of the Cervical Papanicolaou Test Results in the Management of Anal Warts in HIV-Infected WomenReport as inadecuate




Clinical Implications of the Cervical Papanicolaou Test Results in the Management of Anal Warts in HIV-Infected Women - Download this document for free, or read online. Document in PDF available to download.

The Papanicolaou test or Pap test has long been used as a screening tool to detect cervical precancerous-cancerous lesions. However, studies on the use of this test to predict both the presence and change in size of genital warts are limited. We examined whether cervical Papanicolaou test results are associated with the size of the largest anal wart over time in HIV-infected women in an on-going cohort study in the US. A sample of 976 HIV-infected women included in a public dataset obtained from the Women’s Interagency HIV Study WIHS was selected for analysis. A linear mixed model was performed to determine the relationship between the size of anal warts and cervical Pap test results. About 32% of participants had abnormal cervical Pap test results at baseline. In the adjusted model, a woman with a result of Atypia Squamous Cell Undetermined Significance-Low-grade Squamous Intraepithelial Lesion ASCUS-LSIL had an anal wart, on average, 12.81 mm2 larger than a woman with normal cervical cytology. The growth rate of the largest anal wart after each visit in a woman with ASCUS-LSIL was 1.56 mm2 slower than that of a woman with normal cervical results. However, they were not significant P = 0.54 and P = 0.82, respectively. This is the first study to examine the relationship between cervical Pap test results and anal wart development in HIV-infected women. Even though no association between the size of anal wart and cervical Pap test results was found, a screening program using anal cytology testing in HIV-infected women should be considered. Further studies in cost-effectiveness and efficacy of an anal cytology test screening program are warranted.



Author: Hung N. Luu , E. Susan Amirian, R. Palmer Beasley †, Linda Piller, Wenyaw Chan, Michael E. Scheurer

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents