A Prospective Study of the Effect of Different Palliative Radiotherapy Fractionation Schedules on Tumor Response and Toxicity in Advanced Non-Small Cell Lung Cancer NSCLC PatientsReport as inadecuate




A Prospective Study of the Effect of Different Palliative Radiotherapy Fractionation Schedules on Tumor Response and Toxicity in Advanced Non-Small Cell Lung Cancer NSCLC Patients - Download this document for free, or read online. Document in PDF available to download.

Background: with age up to 65 y and Performance Status PS 0 2 and nosignificant cardiac or lung co-morbidities 30 27 AP-PAfields in both arms. response, respiratory functions assessment.Secondary end point was toxicity. Results: 20patients in each arm. There was statistically insignificant higher symptomaticimprovement in arm B. Four weeks after treatment, 12 out of 40 patients 30%,6 patients in each arm, had radiological Partial Response PR of the primarythoracic lesion without significant difference between the two arms. There wasa tendency for improvement in the post treatment mean in botharms up to 4 weeks after treatment. Eleven out of the 40 patients 27.5%, 6 inarm B and 5 in arm A, had radiological signs of radiation pneumonitis withoutsignificant difference between both arms. Conclusion: The two RT fractionationschedules showed equal efficacy in terms of symptoms relief, radiological responseof the primary thoracic tumor, respiratory functions and toxicity. Thus the 27 Gy-10 armto minimize the patients’ visitsand load on the machines.

KEYWORDS

Non-Small Cell Lung Cancer, Palliative Thoracic Radiation, Fractionation Schedules, Symptoms, Randomized Trial

Cite this paper

Lotayef, M. , Elkader, Y. , Amin, A. , Taher, A. , El-Kest, E. and Abdelall, M. 2016 A Prospective Study of the Effect of Different Palliative Radiotherapy Fractionation Schedules on Tumor Response and Toxicity in Advanced Non-Small Cell Lung Cancer NSCLC Patients. Journal of Cancer Therapy, 7, 924-938. doi: 10.4236-jct.2016.712090.





Author: Mohamed Lotayef1, Yaser Abd Elkader2, Amr Amin1*, Azza Taher1, Ehab El-Kest1, Momen Abdelall1

Source: http://www.scirp.org/



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