The Development of an Experimental Multiple Serogroups Vaccine for Neisseria meningitidisReport as inadecuate




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A native outer membrane vesicles NOMV vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide LOS immunotypes, and whose synX, and lpxL1 genes were deleted

Immunogenicity studies in mice showed that the vaccine induced bactericidal antibody against serogroups B, C, W, Y and X N. meningitidis strains. However, this experimental NOMV vaccine was not effective against serogroup A N. meningitidis strains. N. meningitidis capsular polysaccharide PS from serogroups A, C, W and Y were effective at inducing bactericidal antibody when conjugated to either tetanus toxoid or the fHbp1-fHbp2 fusion protein fHbp1+2. The combination of the NOMV vaccine and the N. meningitidis serogroup A capsular polysaccharide MAPS protein conjugate was capable of inducing bactericidal antibodies against a limited number of N. meningitidis strains from serogroups A, B, C, W, Y and X tested in this study.



Author: Valerian B. Pinto , Robert Burden, Allyn Wagner, Elizabeth E. Moran, Che-Hung Lee

Source: http://plos.srce.hr/



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