Bivariate Genome-Wide Association Analysis of the Growth and Intake Components of Feed EfficiencyReport as inadecuate

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Single nucleotide polymorphisms SNPs associated with average daily gain ADG and dry matter intake DMI, two major components of feed efficiency in cattle, were identified in a genome-wide association study GWAS. Uni- and multi-SNP models were used to describe feed efficiency in a training data set and the results were confirmed in a validation data set. Results from the univariate and bivariate analyses of ADG and DMI, adjusted by the feedlot beef steer maintenance requirements, were compared. The bivariate uni-SNP analysis identified P-value <0.0001 11 SNPs, meanwhile the univariate analyses of ADG and DMI identified 8 and 9 SNPs, respectively. Among the six SNPs confirmed in the validation data set, five SNPs were mapped to KDELC2, PHOX2A, and TMEM40. Findings from the uni-SNP models were used to develop highly accurate predictive multi-SNP models in the training data set. Despite the substantially smaller size of the validation data set, the training multi-SNP models had slightly lower predictive ability when applied to the validation data set. Six Gene Ontology molecular functions related to ion transport activity were enriched P-value <0.001 among the genes associated with the detected SNPs. The findings from this study demonstrate the complementary value of the uni- and multi-SNP models, and univariate and bivariate GWAS analyses. The identified SNPs can be used for genome-enabled improvement of feed efficiency in feedlot beef cattle, and can aid in the design of empirical studies to further confirm the associations.

Author: Nick V. L. Serão , Dianelys González-Peña , Jonathan E. Beever, Germán A. Bollero, Bruce R. Southey, Daniel B. Faulkner, Sand



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