MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell CarcinomaReport as inadecuate




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MicroRNAs miRNAs and related polymorphisms have been implicated in the susceptibility to oesophageal squamous cell carcinoma OSCC. In our study, three miRNA-related SNPs: rs6505162 A>C pre-miRNA of miR-423, rs213210 A>G 3’UTR of miR-219-1 and rs7372209 C>T 5’UTR of miR-26a-1 were investigated in the Black and Mixed Ancestry population groups in South Africa. The potential cumulative effects of these SNPs, as well as gene-environment interactions were also analysed. In Blacks, rs6505162 A>C was associated with OSCC under dominant, additive and recessive models with odds ratios ORs 1.353, 1.404, and 2.858, respectively. This locus showed very strong interactions with smoke inhalation from burning wood or charcoal used for heating and cooking in very poorly ventilated areas ORGE=7.855, PGE=9.17*10-10 in the Black group. Furthermore, the miR-423-3p level was 1.39 fold up-regulated in tumour tissues compared to the adjacent normal tissue paired t-test P value 0.0087. SNP-SNP interaction between rs2132210 and rs7372209 was found in both Black and Mixed Ancestry subjects. The AArs213210-CTrs7372209 genotype had a protective effect on OSCC risk in the Black, OR=0.229, P=0.012; and the Mixed Ancestry groups, OR=0.230, P=0.00014. This study is the first to link SNPs in miR-423 together with environmental smoke exposure to risk for developing OSCC.



Author: Yabing Wang, Matjaz Vogelsang, Georgia Schäfer, Marco Matejcic, M. Iqbal Parker

Source: http://plos.srce.hr/



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