Tissue Microarray Immunohistochemical Detection of Brachyury Is Not a Prognostic Indicator in ChordomaReport as inadecuate




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Brachyury is a marker for notochord-derived tissues and neoplasms, such as chordoma. However, the prognostic relevance of brachyury expression in chordoma is still unknown. The improvement of tissue microarray technology has provided the opportunity to perform analyses of tumor tissues on a large scale in a uniform and consistent manner. This study was designed with the use of tissue microarray to determine the expression of brachyury. Brachyury expression in chordoma tissues from 78 chordoma patients was analyzed by immunohistochemical staining of tissue microarray. The clinicopathologic parameters, including gender, age, location of tumor and metastatic status were evaluated. Fifty-nine of 78 75.64% tumors showed nuclear staining for brachyury, and among them, 29 tumors 49.15% showed 1+ <30% positive cells staining, 15 tumors 25.42% had 2+ 31% to 60% positive cells staining, and 15 tumors 25.42% demonstrated 3+ 61% to 100% positive cells staining. Brachyury nuclear staining was detected more frequently in sacral chordomas than in chordomas of the mobile spine. However, there was no significant relationship between brachyury expression and other clinical variables. By Kaplan-Meier analysis, brachyury expression failed to produce any significant relationship with the overall survival rate. In conclusion, brachyury expression is not a prognostic indicator in chordoma.



Author: Linlin Zhang , Shang Guo , Joseph H. Schwab, G. Petur Nielsen, Edwin Choy, Shunan Ye, Zhan Zhang, Henry Mankin, Francis J. Hornic

Source: http://plos.srce.hr/



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