A Reduce and Replace Strategy for Suppressing Vector-Borne Diseases: Insights from a Deterministic ModelReport as inadecuate




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Genetic approaches for controlling disease vectors have aimed either to reduce wild-type populations or to replace wild-type populations with insects that cannot transmit pathogens. Here, we propose a Reduce and Replace RandR strategy in which released insects have both female-killing and anti-pathogen genes. We develop a mathematical model to numerically explore release strategies involving an RandR strain of the dengue vector Aedes aegypti. We show that repeated RandR releases may lead to a temporary decrease in mosquito population density and, in the absence of fitness costs associated with the anti-pathogen gene, a long-term decrease in competent vector population density. We find that RandR releases more rapidly reduce the transient and long-term competent vector densities than female-killing releases alone. We show that releases including RandR females lead to greater reduction in competent vector density than male-only releases. The magnitude of reduction in total and competent vectors depends upon the release ratio, release duration, and whether females are included in releases. Even when the anti-pathogen allele has a fitness cost, RandR releases lead to greater reduction in competent vectors than female-killing releases during the release period; however, continued releases are needed to maintain low density of competent vectors long-term. We discuss the results of the model as motivation for more detailed studies of RandR strategies.



Author: Michael A. Robert , Kenichi Okamoto, Alun L. Lloyd, Fred Gould

Source: http://plos.srce.hr/



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