Association between MGMT Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-AnalysisReport as inadecuate




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Background

O6-methylguanine-DNA methyltransferase MGMT is one of most important DNA repair enzyme against common carcinogens such as alkylate and tobacco. Aberrant promoter methylation of the gene is frequently observed in non-small cell lung cancer NSCLC. However, the importance of epigenetic inactivation of the gene in NSCLC published in the literature showed inconsistence. We quantified the association between MGMT promoter methylation and NSCLC using a meta-analysis method.

Methods

We systematically reviewed studies of MGMT promoter methylation and NSCLC in PubMed, EMBASE, Ovid, ISI Web of Science, Elsevier and CNKI databases and quantified the association between MGMT promoter methylation and NSCLC using meta-analysis method. Odds ratio OR and corresponding 95% confidence interval CI were calculated to evaluate the strength of association. Potential sources of heterogeneity were assessed by subgroup analysis and meta-regression.

Results

A total of 18 studies from 2001 to 2011, with 1, 160 tumor tissues and 970 controls, were involved in the meta-analysis. The frequencies of MGMT promote methylation ranged from 1.5% to 70.0% median, 26.1% in NSCLC tissue and 0.0% to 55.0% median, 2.4% in non-cancerous control, respectively. The summary of OR was 4.43 95% CI: 2.85, 6.89 in the random-effects model. With stratification by potential source of heterogeneity, the OR was 20.45 95% CI: 5.83, 71.73 in heterogeneous control subgroup, while it was 4.16 95% CI: 3.02, 5.72 in the autologous control subgroup. The OR was 5.31 95% CI: 3.00, 9.41 in MSP subgroup and 3.06 95% CI: 1.75, 5.33 in Q-MSP subgroup.

Conclusion

This meta-analysis identified a strong association between methylation of MGMT gene and NSCLC. Prospective studies should be required to confirm the results in the future.



Author: Changmei Gu, Jiachun Lu, Tianpen Cui, Cheng Lu, Hao Shi, Wenmao Xu, Xueli Yuan, Xiaobo Yang, Yangxin Huang, Meixia Lu

Source: http://plos.srce.hr/



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