Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive PatientsReport as inadecuate




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We have recently identified a novel population of activated low-density granulocytes LDGs in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes NDGs, but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.



Author: Tom Cloke, Markus Munder, Philip Bergin, Shanthi Herath, Manuel Modolell, Graham Taylor, Ingrid Müller, Pascale Kropf

Source: http://plos.srce.hr/



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