Carbohydrate Intake Is Correlated with the Glycated Albumin to Glycated Hemoglobin Ratio in Drug-Naive Patients with Type 2 DiabetesReport as inadecuate




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Background: The glycated albumin GA to HbA1c ratio GA-HbA1c ratio has beenreported to reflect postprandial hyperglycemia. Carbohydrate is the primarydietary macronutrient that causes postprandial hyperglycemia. Thus, weinvestigated whether carbohydrate intake was associated with the GA-HbA1c ratioin patients with type 2 diabetes. Methods:Daily energy intake and carbohydrate intake were estimated in twenty-two patientswith type 2 diabetes who received no pharmacological therapy 18 men and 4women, age 53 ± 11 years old. The energy index and the carbohydrate index weredefined as the ratio of daily energy intake to body weight and daily carbohydrateintake to body weight, respectively. Results:The energy index was significantly correlated with the GA-HbA1c ratio r = 0.451,p = 0.035, but not with fasting plasma glucose FPG, HbA1c and GA. The carbohydrateindex was significantly correlated with GA r = 0.461, p = 0.031 and theGA-HbA1c ratio r = 0.554, p = 0.007, but not with FPG and HbA1c. Multivariateanalysis revealed that the carbohydrate index was independently associated withthe GA-HbA1c ratio β = 0.397, p = 0.046. Conclusions: The carbohydrate index wassignificantly correlated with GA and the GA-HbA1c ratio in the patients withtype 2 diabetes. These results suggest that carbohydrate intake may beassociated with the GA-HbA1c ratio through postprandial hyperglycemia.

KEYWORDS

Glycated Albumin, HbA1c, Type 2 Diabetes Mellitus, Carbohydrate, Postprandial Hyperglycemia

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Sumitani, S. , Utsu, Y. , Nishina, S. , Okuro, K. , Kogetsu, A. , Ishii, S. , Deguchi, A. , Sato, B. , Tachibana, I. , Kasayama, S. and Koga, M. 2016 Carbohydrate Intake Is Correlated with the Glycated Albumin to Glycated Hemoglobin Ratio in Drug-Naive Patients with Type 2 Diabetes. Journal of Diabetes Mellitus, 6, 10-15. doi: 10.4236-jdm.2016.61002.





Author: Satoru Sumitani1,2*, Yoshihiko Utsu1,2, Shuhei Nishina1,2, Kenta Okuro1,2, Atsushi Kogetsu2, Seigo Ishii2, Akiko Deguchi1, Bunzo

Source: http://www.scirp.org/



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