Retroviral-mediated overexpression of human bone morphogenetic protein 2 affects human mesenchymal stem cells during monolayer proliferation: a cautionary note Report as inadecuate




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Mauro Alini ; Charles W. Archer ; Martin J. Stoddart ;Electronic Journal of Biotechnology 2013, 16 2

Author: Alexander J. Neumann

Source: http://www.redalyc.org/


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Electronic Journal of Biotechnology E-ISSN: 0717-3458 edbiotec@ucv.cl Pontificia Universidad Católica de Valparaíso Chile Neumann, Alexander J.; Alini, Mauro; Archer, Charles W.; Stoddart, Martin J. Retroviral-mediated overexpression of human bone morphogenetic protein 2 affects human mesenchymal stem cells during monolayer proliferation: A cautionary note Electronic Journal of Biotechnology, vol.
16, núm.
2, 2013, pp.
1-7 Pontificia Universidad Católica de Valparaíso Valparaíso, Chile Available in: http:--www.redalyc.org-articulo.oa?id=173325727007 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Electronic Journal of Biotechnology ISSN: 0717-3458 http:--www.ejbiotechnology.info DOI: 10.2225-vol16-issue2-fulltext-2 TECHNICAL NOTE Retroviral-mediated overexpression of human bone morphogenetic protein 2 affects human mesenchymal stem cells during monolayer proliferation: A cautionary note Alexander J.
Neumann1,2 ∙ Mauro Alini1 ∙ Charles W.
Archer2 ∙ Martin J.
Stoddart1 1 AO Foundation, AO Research Institute Davos, Musculoskeletal Regeneration Program, Davos Platz, Switzerland 2 Cardiff University, Cardiff School of Biosciences, Cardiff, U.K. Corresponding author: martin.stoddart@aofoundation.org Received August, 2012 - Accepted January 23, 2013 Published online: March 15, 2013 © 2013 by Pontificia Universidad Católica de Valparaíso, Chile Abstract Background: Retroviral vectors are commonly used for gene transfer applications and they represent an effective way to provide a sustained delivery of a bioactive factor in basic research and tissue engineering applications.
Cells that have been transduced with retroviral vectors ex vivo are usually amplified on tissue culture plastic, for a prolonged period of time, i...





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