The Prognostic Value of SOX2 Expression in Non-Small Cell Lung Cancer: A Meta-AnalysisReport as inadecuate




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Objective

To investigate the association of SOX2 expression in tumor with clinicopathological features and survival of non-small-cell lung carcinoma NSCLC patients.

Methods

Publications assessing the clinicopathological characteristics and prognostic significance of SOX2 in NSCLC were identified up to May 2013. A meta-analysis of eligible studies was performed using standard statistical methods to clarify the association between SOX2 expression and these clinical parameters.

Results

A total of eight studies met the inclusion criteria. Analysis of these data showed that SOX2 expression was positively associated with squamous histology, pooled OR = 5.26, 95% CI: 1.08–25.6, P = 0.040. Simultaneously, we also found that SOX2 expression was positively associated with overall survival pooled HR = 0.65, 95% CI: 0.47–0.89, P = 0.007, random-effect.

Conclusions

SOX2 expression in tumor is a candidate positive prognostic biomarker for NSCLC patients.



Author: Yansu Chen , Yefei Huang , Yulin Huang , Junjie Chen, Shouyu Wang , Jianwei Zhou

Source: http://plos.srce.hr/



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