Joint T1 and brain fiber diffeomorphic registration using the demonsReport as inadecuate

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1 LNAO - Laboratoire de Neuroimagerie Assistée par Ordinateur 2 PARIETAL - Modelling brain structure, function and variability based on high-field MRI data Inria Saclay - Ile de France 3 ASCLEPIOS - Analysis and Simulation of Biomedical Images CRISAM - Inria Sophia Antipolis - Méditerranée

Abstract : Image registration is undoubtedly one of the most active areas of research in medical imaging. Within inter-individual comparison, registration should align images as well as cortical and external structures such as sulcal lines and fibers. While using image-based registration1, neural fibers appear uniformly white giving no information to the registration. Tensor-based registration was recently proposed to improve white-matter alignment2,3, however misregistration may also persist in regions where the tensor field appears uniform4. We propose an hybrid approach by extending the Diffeomorphic DemonsD5 registration to incorporate geometric constrains. Combining the deformation field induce by the image and the geometry, we define a mathematically sound framework to jointly register images and geometric descriptors such as fibers or sulcal lines.

Author: Viviana Siless - Pamela Guevara - Xavier Pennec - Bertrand Thirion - Pierre Fillard -



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