Correlation of Ceruloplasmin with Biomarkers of Cardiac Remodelling and Myofibrosis in Patients with Acute Decompensated Heart Failure Referred to a Tertiary Nurse Lead Heart Failure ClinicReport as inadecuate




Correlation of Ceruloplasmin with Biomarkers of Cardiac Remodelling and Myofibrosis in Patients with Acute Decompensated Heart Failure Referred to a Tertiary Nurse Lead Heart Failure Clinic - Download this document for free, or read online. Document in PDF available to download.

Background: Ceruloplasmin is an acute phase protein with plasma copper binding properties, and is a potent extracellular antioxidative enzyme. Inflammation and oxidative stress might explain the role of ceruloplasmin in the pathophysiology of heart failure. Study objective: The objective is to assess the correlation of ceruloplasmin levels with biomarkers of cardiac remodelling and myofibrosis in patients with acute decompensated heart failure. Patients and methods: Blood samples were taken and serum levels of soluble ST2, galectin-3, NT-proBNP and ceruloplasmin were analysed in 31 consecutive patients with systolic HF referred to tertiary care nurse lead heart failure clinic with acute decompensated CHF requiring i.v. diuretics. The mean patients’ age was 68 years, mean left ventricular ejection fraction LV EF was 29%, 66% patients had ischemic aetilogy of CHF and 33% had atrial fibrillation. Results: The mean ceruloplasmin level was 0.243 g-l, mean galectin-3 level was 1.26 ng-ml, mean sST2 level was 38.15 ng-ml, and mean NT-proBNP was 1927 pg-ml. The ceruloplasmin level correlated with NT-proBNP r = 0.58, p < 0.05 and with sST2 r = 0.77, p < 0.001, sST2 levels correlated significantly with NT-proBNP r = 0.66, p < 0.01. The ceruloplasmin level did not correlate with galectin-3 concentration. Conclusion: The ceruloplasmin level correlates with the biomarkers of cardiac remodelling NT-proBNP, sST2, but not with the biomarker of myofibrosis galectin-3. This finding supports the hypothesis of inflammatory response in acute decompensated heart failure.

KEYWORDS

Acute Decompensated Heart Failure, Ceruloplasmin, NT-proBNP, sST2, Galectin-3

Cite this paper

Málek, F. , Vondráková, D. , Komendová, O. , Říhová, D. , Vránová, J. , Sedláčková, L. , Andreasová, T. and Neužil, P. 2015 Correlation of Ceruloplasmin with Biomarkers of Cardiac Remodelling and Myofibrosis in Patients with Acute Decompensated Heart Failure Referred to a Tertiary Nurse Lead Heart Failure Clinic. Open Journal of Nursing, 5, 971-975. doi: 10.4236-ojn.2015.511103.





Author: Filip Málek1,2*, Dagmar Vondráková1,2, Oxana Komendová1, Dana Říhová1, Jana Vránová2, Lenka Sedláčková3, Táňa Andre

Source: http://www.scirp.org/



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