GABAb Receptor Antagonist CGP35348 Improves Testosterone Induced Spatial Acquisition Impairment in Adult Male RatReport as inadecuate




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The high density ofthe androgen receptors in fundamental centers of learning and memory, such ashippocampus, shows that there must be some relationship between the androgen receptorsand cognitive aspects. On the other hand, Gama Amino Butric Acid GABA plays acontrolling role in the balance of excitability and inhibitory states in thecortex and hippocampus; a number of reports suggest that removal of theinfluence of inhibitory GABA receptors lead to memory enhancement andconversely the activation lead to memory inhibition. Sex steroids can rapidly influenceneural activity by increasing the binding affinity of neurotransmitters such asGABAergic. To determine the effect of Testosterone on learning and memory in CA1 region of hippocampus, male albino Wistar rats 200 - 250 g are bilaterallycannulated into CA1 of hippocampus then different doses of Testosteroneenanthate or CGP35348 are injected through the cannulae forassessing of acquisition, consolidation and retrieval in a single-day testingprotocol of Morris water maze task. After hippocampal microinjection with TestosteroneT, acquisition is significantly impaired, while after treatment with CGP35348,acquisition impairment caused by T can be significantly improved. Also T andCGP35348 have no significant effect on consolidation and retrievalstages of spatial memory. These results suggest that CGP35348 mayhave therapeutic value in the treatment of Testosterone-induced acquisition impairment.

KEYWORDS

Spatial Learning and Memory, Hippocampus, Testosterone, CGP35348, Morris Water Maze

Cite this paper

Shahrzad, P. and Nasser, N. 2015 GABAb Receptor Antagonist CGP35348 Improves Testosterone Induced Spatial Acquisition Impairment in Adult Male Rat. Journal of Behavioral and Brain Science, 5, 491-502. doi: 10.4236-jbbs.2015.511047.





Author: Pourang Shahrzad, Naghdi Nasser*

Source: http://www.scirp.org/



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