A Study on the Safety of Liver Biopsy Inpatients with Von Willebrand’s DiseaseReport as inadecuate




A Study on the Safety of Liver Biopsy Inpatients with Von Willebrand’s Disease - Download this document for free, or read online. Document in PDF available to download.

Objectives: Liver biopsy remains the gold standard for diagnosis of chronic liver diseases. Outpatient percutaneous biopsy is generally safe with a mortality rate of 0.17% and hospitalization rate for bleeding of 3%. Von Willebrand disease vWD syndrome is the most common inherited hematological disorder with a prevalence of 1% - 3% globally. We sought to study whether vWD increases the risk of bleeding for liver biopsies. Methods: All patients n = 120 who underwent outpatient percutaneous liver biopsies from 1997 to 2007 were analyzed. Demographics, PT-INR, platelet count, vW antigen and ristocetin induced platelet aggregation were studied. Results: No vWD patients had major bleeding that required transfusion, hospitalization or surgery but 9 75% had minor local bleeding and all had ecchymosis, which resolved spontaneously within 24 hours. Conclusions: Patients with vW factor deficiency can undergo percutaneous liver biopsy without major bleeding. Minor bleeding may occur at a slightly higher rate. vWD is not a contraindication to percutaneous liver biopsy.

KEYWORDS

Liver Biopsy, vW Disease, Safety, Complications

Cite this paper

Basu, P. , Shah, N. , Aloysius, M. , Rayapudi, K. and Brown, R. 2015 A Study on the Safety of Liver Biopsy Inpatients with Von Willebrand’s Disease. Open Journal of Gastroenterology, 5, 134-138. doi: 10.4236-ojgas.2015.59022.





Author: Patrick P. Basu1,2, Niraj J. Shah3, Mark M. Aloysius4, K. Rayapudi2, Robert Brown2

Source: http://www.scirp.org/



DOWNLOAD PDF




Related documents