The Mechanism of Decreased Serum Phosphorus Levels in Rats with Chronic Kidney Disease after Oral Administration of Bifidobacterium longumReport as inadecuate




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Chronickidney disease CKD patients are prone to disturbances in the intestinalmicrobiota, which contributes to CKD progression and complications. Wepreviously reported a reduction of serum phosphorus P levels in hemodialysis patients receivingoral encapsulated bifidobacteria. The present study was conducted to clarifythe mechanisms of P-lowering effect of bifidobacteria on CKD rats. CKD wasinduced in rats by 5-6 nephrectomy. Five weeks later, the rats were fed for 4weeks on a powder diet containing encapsulated bifidobacteria. At the end ofthe study, intestinal contents were sampled for analyses of pH, intestinal floraand short-chain fatty acids SCFAs. Oral administration of bifidobacteriahalted the onset and progression of hyperphosphatemia in CKD rats. Theincreased number of bifidobacteria was confirmed in the cecum. In addition, theincrease in intestinal pH in CKD rats was decreased after bifidobacteriatreatment, along with increases in some SCFAs. Furthermore, positivecorrelation between serum P levels and intestinal pH was observed. Inconclusion, the mechanism for the P-lowering effect of bifidobacteria wassupposed as follows: CKD conditions increase aerobic bacteria which hydrolyzeurea into ammonia. Elevated pH decreases ionization of intestinal calcium Cawhich leads to an increase in free phosphate ions through reduction of Caphosphate crystal precipitation. Administered bifidobacteria fermentedcarbohydrates to produce SCFAs, resulting in acidification of the intestinallumen. The resulting low intestinal pH increases Ca ionization, which bindswith free phosphate ions as an intrinsic P binder, resulting in the reduction ofserum P levels.

KEYWORDS

Bifidobacteria, CKD-MBD, Dysbiosis, Hyperphosphatemia, Intestinal pH, Short-Chain Fatty Acids

Cite this paper

Nagano, N. , Futaya, M. , Kohno, M. , Nakano, O. , Nishida, N. , Matsuura, Y. , Shimada, M. , Ito, K. , Ando, T. , Tsutsui, T. , Ando, Y. , Omae, K. , Nitta, K. , Sakura, H. and Ogawa, T. 2015 The Mechanism of Decreased Serum Phosphorus Levels in Rats with Chronic Kidney Disease after Oral Administration of Bifidobacterium longum. Advances in Microbiology, 5, 531-540. doi: 10.4236-aim.2015.57055.





Author: Nobuo Nagano1,2*, Mayuko Futaya2, Mamiko Kohno3, Osami Nakano3, Norihisa Nishida3, Yoichi Matsuura3, Mikiko Shimada1, Kyoko Ito1,

Source: http://www.scirp.org/



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