The Protective Effect of Compound Danshen Dripping Pills on Oxidative Stress after Retinal Ischemia-Reperfusion Injury in RatsReport as inadecuate




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Objective: To investigate the effect of Compound Danshen Dripping Pills CDDP on oxidative stress after ischemia-reperfusion I-R injury in the rat retina. Methods: Adult male SD rats were randomly divided into 3 groups: sham group A, I-R group B, and I-R plus CDDP group C. Retinal ischemia-reperfusion injury RIRI was introduced by increasing the intraocular pressure IOP to 110 mmHg for 60 min via cannulation into the anterior chamber. Right after the insult, CDDP was administered intragastrically 450 mg-kg-d for 7 days. The levels of malondialdehyde MDA, the activities of superoxide dismutase SOD, glutathione peroxidase GSH-Px, and catalase CAT in the retinal tissues were determined on d1 and d7 after the ischemic insult. Results: Following ischemia, the MDA levels in group B and group C were significantly higher than those in group A p < 0.01. CDDP significantly lowered MDA levels in group C when compared with group B p < 0.01. The activities of SOD, GSH-Px and CAT were higher in group A than in group B and group C p < 0.01. CDDP could increase the activities of SOD, GSH-Px and CAT remarkably in group C when compared with group B p < 0.01. Conclusion: CDDP can protect the retina from I-R injury through reducing oxidative stress, and thus may be a promising method for the treatment of ischemic retinal disorders.

KEYWORDS

Compound Danshen Dripping Pills CDDP, Retinal Ischemia-Reperfusion Injury RIRI, Oxidative Stress, Rats

Cite this paper

Lu, B. and Wu, X. 2015 The Protective Effect of Compound Danshen Dripping Pills on Oxidative Stress after Retinal Ischemia-Reperfusion Injury in Rats. Chinese Medicine, 6, 90-96. doi: 10.4236-cm.2015.62010.





Author: Bingwen Lu, Xingwei Wu*

Source: http://www.scirp.org/



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