Bronchial-pulmonary adenocarcinoma subtyping relates with different molecular pathways Report as inadecuate




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Bruno Bastos ; Maria Silva ; Ana Maria Alarcão ; Lina Carvalho ;Revista Portuguesa de Pneumología 2015, 21 5

Author: Vítor Sousa

Source: http://www.redalyc.org/


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Revista Portuguesa de Pneumología ISSN: 0873-2159 sppneumologia@mail.telepac.pt Sociedade Portuguesa de Pneumologia Portugal Sousa, Vítor; Bastos, Bruno; Silva, Maria; Alarcão, Ana Maria; Carvalho, Lina Bronchial-pulmonary adenocarcinoma subtyping relates with different molecular pathways Revista Portuguesa de Pneumología, vol.
21, núm.
5, septiembre-octubre, 2015, pp.
259270 Sociedade Portuguesa de Pneumologia Lisboa, Portugal Available in: http:--www.redalyc.org-articulo.oa?id=169741611008 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Document downloaded from http:--www.elsevier.pt, day 10-09-2015.
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Any transmission of this document by any media or format is strictly prohibited. Rev Port Pneumol.
2015;21(5):259---270 www.revportpneumol.org ORIGINAL ARTICLE Bronchial-pulmonary adenocarcinoma subtyping relates with different molecular pathways Vítor Sousa a,b,∗ , Bruno Bastos a , Maria Silva a , Ana Maria Alarcão a , Lina Carvalho a,b a b IAP-FMUC-Institute of Pathology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal Pathology Institute, Coimbra University Hospital (HUC-CHUC), Coimbra, Portugal Received 30 October 2013; accepted 30 May 2014 Available online 6 March 2015 KEYWORDS Lung; Adenocarcinoma; APC; BCL2; Cyclin D1; EGFR; ERCC1; HER2; LRP; MRP ∗ Abstract Lung cancer is one of the most common cancers in the world with a high mortality rate.
We analyzed 45 surgical samples of the adenocarcinoma, 13 with lymph node metastasis. APC, BCL2, chromogranin A, CK 5-6-18 (LP34), CK20, CK7, cyclin D1, EGFR, ERCC1, HER2, Ki67, LRP, MRP, P53, RB and TTF1 expressions were evaluated by immunohistochemistry (IHC). Higher Ki67, APC, ERCC1 expressions and lower TTF1 expressio...





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