Short-Term Soy Isoflavone Intervention in Patients with Localized Prostate Cancer: A Randomized, Double-Blind, Placebo-Controlled TrialReport as inadecuate




Short-Term Soy Isoflavone Intervention in Patients with Localized Prostate Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial - Download this document for free, or read online. Document in PDF available to download.

Purpose

We describe the effects of soy isoflavone consumption on prostate specific antigen PSA, hormone levels, total cholesterol, and apoptosis in men with localized prostate cancer.

Methodology-Principal Findings

We conducted a double-blinded, randomized, placebo-controlled trial to examine the effect of soy isoflavone capsules 80 mg-d of total isoflavones, 51 mg-d aglucon units on serum and tissue biomarkers in patients with localized prostate cancer. Eighty-six men were randomized to treatment with isoflavones nā€Š=ā€Š42 or placebo nā€Š=ā€Š44 for up to six weeks prior to scheduled prostatectomy. We performed microarray analysis using a targeted cell cycle regulation and apoptosis gene chip GEArrayTM. Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol were analyzed at baseline, mid-point, and at the time of radical prostatectomy. In this preliminary analysis, 12 genes involved in cell cycle control and 9 genes involved in apoptosis were down-regulated in the treatment tumor tissues versus the placebo control. Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol in the isoflavone-treated group compared to men receiving placebo were not statistically significant.

Conclusions-Significance

These data suggest that short-term intake of soy isoflavones did not affect serum hormone levels, total cholesterol, or PSA.

Trial Registration

ClinicalTrials.gov NCT00255125



Author: Jill M. Hamilton-Reeves , Snigdha Banerjee, Sushanta K. Banerjee, Jeffrey M. Holzbeierlein, J. Brantley Thrasher, Suman Kambhampa

Source: http://plos.srce.hr/



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