11C-Labeling of the C1-C10 Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide-2 PET TracerReport as inadecuate




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11C-labeled C1-C10 partial structure of kulokekahilide-2 1 was successfully synthesized based on Pd0-mediated rapid C-11Cmethylation using 11Cmethyl iodide and pinacol alkenylboronate. The preparation of organoboron intermediate via olefin cross-metathesis is also a crucial procedure for the synthesis of 11C-labeling C1-C10 dihy-droxy acid moiety of 1.

KEYWORDS

Kulokekahilide-2, Carbon-11, Boron, C-C Coupling, Isotopic Labeling

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Han, C. , Doi, H. , Kimura, J. , Nakao, Y. and Suzuki, M. 2014 11C-Labeling of the C1-C10 Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide-2 PET Tracer. International Journal of Organic Chemistry, 4, 269-277. doi: 10.4236-ijoc.2014.44029.





Author: Chunguang Han1, Hisashi Doi2, Junji Kimura3, Yoichi Nakao4, Masaaki Suzuki5*

Source: http://www.scirp.org/



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