Paroxetine Increased the Serum Estrogen in Postmenopausal Women with Depressive and Anxiety SymptomsReport as inadecuate




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Objective: Both of selective serotonin reuptake inhibitors SSRIs and estrogen can modulate emotion and cognition function in post-menopause women, moreover SSRIs can influence estrogen system in rats and aquatic wildlife but most of them for reproductive ability. The aim of this study was to investigate the possible relationship between SSRI, estrogen, and emotion and cognition in post-menopause women with anxiety and depressive symptoms .Methods: A double-blind, randomized controlled trials of Paroxetine, an SSRI n = 44, versus placebo n = 38 for 6 months in post-menopausal women with anxiety and depressive symptoms. For screening anxiety, depression and mild cognitive impairment MCI, we use the Hamilton Anxiety Rating Scale HAM-A, the Hamilton Depression Rating Scale HAM-D and the Chinese Version of the Montreal cognitive assessment MoCA-CV. And sex hormones were measured by ELASE method which is serum estradiol E2, follicle stimulating hormone FSH and luteinizing hormone LH. Results: Paroxetine increased serum E2 and decreased LH, FSH significantly P < 0.05. Meanwhile, HAM-A and HAM-D scores declined and MoCA-CV score raised by Paroxetine P < 0.05. We also found that a negative association between E2 and scores of HAM-A and HAM-D at pre-treatment and post-treatment of Paroxetine HAM-A: R = ?0.27, R = ?0.24; HAM-D: R = ?0.65, R = ?0.37, while a positive correlation between E2 and MoCA-CV scores R = 0.52, R = 0.47. Conclusions: This founding suggests that SSRI can increase serum estrogen levels and the change of estrogen may be one of mechanism in SSRI’s improve emotion and cognitive function in post-menopausal women.

KEYWORDS

Paroxetine, Estrogen, Anxiety or Depressive Symptom, Cognition, Post-Menopausal Women

Cite this paper

Zhou, B. , Xie, S. , Hu, J. , Sun, X. , Guan, H. and Deng, Y. 2014 Paroxetine Increased the Serum Estrogen in Postmenopausal Women with Depressive and Anxiety Symptoms. Open Journal of Depression, 3, 184-194. doi: 10.4236-ojd.2014.35022.





Author: Borong Zhou*, Shuangyan Xie, Jiajia Hu, Xiaofang Sun, Haitao Guan, Yanhua Deng

Source: http://www.scirp.org/



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