Findings of 18F-Fluorodeoxyglucose Positron-Emission Tomography in Methotrexate-Related Lymphoproliferative DisorderReport as inadecuate




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Introduction: The use of methotrexate MTX for rheumatoid arthritis RA is increasing. However, the immune suppression state leads to the occurrence of lymphoproliferative disorder MTX-LPD. The purpose of this study was to describe the findings of 18F-fluorodeoxyglucose FDG positron emission tomography PET in MTX-LPD patients, and compare it with non-MTX-related malignant lymphoma ML. Materials and Methods: We retrospectively reviewed 11 MTX-LPD patients 9 female, mean age 68.3 years and 21 ML patients 7 female, mean age 60.6 years with a histopathological diagnosis. FDG-PET imaging was performed using a standard oncology procedure. We assessed the disease distribution based on FDG-PET images and measured the maximum standardized up take values SUVmax for each region. Results: Mean values of SUVmax in MTX-LPD and ML were 14.6 and 17.2, respectively p = 0.49. In MTX-LPD, 55 lesions met the Cotswold classification, consisting of 37 nodal and 18 extranodal lesions. In ML, 82 lesions were found, consisting of 68 nodal and 14 extranodal lesions. MTX-LPD showed a higher incident of the involvement in extranodal lesions throughout the whole body p < 0.001. Conclusion: Because this disease occurs widely throughout the whole body, we need to pay attention to the less frequent sites as well when performing PET imaging in patients with MTX-LPD.

KEYWORDS

Fluorodeoxyglucose FDG F 18, Lymphoma, Methotrexate, Positron-Emission Tomography PET, Rheumatoid Arthritis

Cite this paper

Kono, A. , Kitajima, K. , Mmatsuoka, H. , Otani, K. , Itoh, T. and Sugimura, K. 2014 Findings of 18F-Fluorodeoxyglucose Positron-Emission Tomography in Methotrexate-Related Lymphoproliferative Disorder. Open Journal of Radiology, 4, 293-300. doi: 10.4236-ojrad.2014.44038.





Author: Atsushi K. Kono1, Kazuhiro Kitajima2, Hiroshi Mmatsuoka3, Kyoko Otani4, Tomoo Itoh4, Kazuro Sugimura2

Source: http://www.scirp.org/



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