Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based StudyReport as inadecuate




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Background

Cardiovascular risk factors CRFs such as smoking and diabetes have been associated with mobility limitations among older adults. We seek to examine to what extent individual and aggregated CRFs and cardiovascular diseases CVDs are associated with mobility limitation.

Methods

The study sample included 2725 participants age ≥60 years, mean age 72.7 years, 62% women in the Swedish National Study on Aging and Care in the Kungsholmen district of central Stockholm, Sweden, who were living either at their own home or in institutions. Data on demographic features, CRFs, and CVDs were collected through interview, clinical examination, self-reported history, laboratory tests, and inpatient register. Mobility limitation was defined as walking speed <0.8 m-s. Data were analyzed using multiple logistic models controlling for potential confounders.

Results

Of the 2725 participants, 581 21.3% had mobility limitation. The likelihood of mobility limitation increased linearly with the increasing number of CRFs i.e., hypertension, high C-reactive protein, obesity, diabetes and smoking p for linear trend<0.010 and of CVDs i.e., ischemic heart disease, atrial fibrillation, heart failure and stroke p for linear trend<0.001. There were statistical interactions of aggregated CRFs with age and APOE ε4 allele on mobility limitation pinteraction<0.05, such that the association of mobility limitation with aggregated CRFs was statistically evident only among people aged <80 years and among carriers of the APOE ε4 allele.

Conclusion

Aggregations of multiple CRFs and CVDs are associated with an increased likelihood of mobility limitation among older adults; however the associations of CRFs with mobility limitation vary by age and genetic susceptibility.



Author: Anna-Karin Welmer , Sara Angleman, Elisabeth Rydwik, Laura Fratiglioni, Chengxuan Qiu

Source: http://plos.srce.hr/



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