Down-Regulation of Claudin-1 Expression in Gastric Cancer Mucosa Is Correlated with Poor PrognosisReport as inadecuate




Down-Regulation of Claudin-1 Expression in Gastric Cancer Mucosa Is Correlated with Poor Prognosis - Download this document for free, or read online. Document in PDF available to download.

Background: Cell adhesion molecule abnormalities are given as one reason for the occurrence of invasion and metastasis in various cancers. In this study, we conducted an immunohistochemical examination of cell adhesion molecule claudin-1 in mucosa and invasive front of gastric cancer, and investigated the correlation of claudin-1 expression and clinicopathological factors. Methods: Immunohistochemical examination was performed for 35 patients who underwent surgery be-tween January 2010 and October 2011, to assess the correlation of claudin-1 with primary gastric cancer. Results: The expression rate of claudin-1 was 48.6% 17-35 in 35 gastric carcinoma patients. The positive rates of claudin-1 were 42.9% 15-35 in mucosa and 28.6% 10-35 in invasive front of gastric cancer. The expression rate of claudin-1 in invasive front was lower than in mucosa. From comparing claudin-1 expression in mucosa, it was found that well-to moderately-differentiated adenocarcinoma had significantly more claudin-1 expression than poorly-differrentiated adenocarcinoma. Claudin-1 expression of well-to moderately-differentiated adenocar-cinoma decreased in the invasive front of gastric cancer. Expression of claudin-1 in mucosa was negative in many cases with advanced tumor invasion T2, T3, T4 and positive in many cases with early tumor invasion T1, with a significant difference between the two p < 0.05. In mucosa, many cases at an advanced stage Stage II, III, IV were negative for claudin-1 expression and many cases at an early stage Stage I were positive for claudin-1 expression. A significant difference was seen between the two p < 0.05. However, claudin-1 expression in the invasive front was not correlated with histological type, depth of tumor invasion and stage. Conclusion: From the above results, it is considered that decreased claudin-1expression in mucosa is related to histological type, gastric cancer invasion and stage, and this information may be useful when making a pathological diagnosis of advanced gastric cancer and estimating outcomes.

KEYWORDS

Claudin-1, Immunohistochemistry, Mucosa, Invasive Front, Gastric Cancer

Cite this paper

Hirakawa, E. , Tokuhara, Y. , Morinishi, T. , Ohsaki, H. , Uemura, E. , Miki, Y. , Matsunaga, T. , Kushida, Y. and Haba, R. 2014 Down-Regulation of Claudin-1 Expression in Gastric Cancer Mucosa Is Correlated with Poor Prognosis. Open Journal of Pathology, 4, 206-212. doi: 10.4236-ojpathology.2014.44026.





Author: Eiichiro Hirakawa1*, Yasunori Tokuhara1, Tatsuya Morinishi1, Hiroyuki Ohsaki2, Erika Uemura3, Yukari Miki4, Toru Matsunaga3, Yosh

Source: http://www.scirp.org/



DOWNLOAD PDF




Related documents