Antineutrophil Cytoplasmic Antibodies ANCA: Diagnostic Utility and Potential Role in the Pathogenesis of VasculitisReport as inadecuate




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Acta dermatovenerologica Croatica, Vol.12 No.4 April 2004. -

Antineutrophil cytoplasmic antibodies ANCA are a heterogeneous group of circulating antibodies directed toward the cytoplasmic constituents of neutrophils and monocytes. ANCA have been de scribed in various diseases including idiopathic systemic vasculitides, connective tissue diseases,

inflammatory bowel diseases, autoimmune liver diseases, infectious diseases,

and some drugs. ANCA recognize different target antigens such as proteinase

3 PR3-ANCA, myeloperoxidase MPO-ANCA, cathepsin G, lactoferrin, bactericidal-permeability-increasing protein BPI, and some others. However,

only PR3-ANCA and MPO-ANCA are closely associated with systemic vasculitides, in particular Wegeners granulomatosis, microscopic polyangiitis and its

renal limited manifestation, and Churg-Strauss syndrome. Both in vitro and in

vivo experimental data strongly support a pathogenic role for ANCA in vasculitis and glomerulonephritis.

ANCA; PR3-ANCA; MPO-ANCA; vasculitis; pathogenesis



Author: Branko Malenica - et al. -

Source: http://hrcak.srce.hr/



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