From Circumscribed Scleroderma Morphea to Subcutaneous Panniculitis-Like T-Cell Lymphoma: Case ReportReport as inadecuate




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Acta dermatovenerologica Croatica, Vol.12 No.4 April 2004. -

Subcutaneous panniculitis-like T-cell lymphoma is a rare form

of non-Hodgkin lymphoma. It presents clinically as panniculitis, with

erythematous, firm subcutaneous infiltrates and recurrent papulonodules.

A 45-year-old male Croat presented with a 6-month history of tender

erythematous subcutaneous skin lesions without systemic symptoms.

Analysis of a lesion biopsy specimen showed circum scribed scleroderma

morphea. During hospitalization, skin biopsies from two subcutaneous lesions on the stom ach were repeated, and pathohistologic analysis corresponded primarily to panniculitis in the context of morphea. Pathohistologic

analysis and immunohistochemistry of a specimen obtained by tumor ex cision from the back indicated subcutaneous panniculitis-like T-cell lymphoma. Histologic analysis re vealed a dense infiltrate of atypical T-lymphoid cells expressing CD8+ phenotype located in the subcutaneous tissue with histiocyte-phagocytizing apoptotic cells. Specific hematologic

analysis and medical treatment were continued. This case report illustrates

the importance of continuous follow-up with repeat biopsy and use of

immunohistologic techniques for early diagnosis.

subcutaneous panniculitis-like T-cell lymphoma; circumscribed scleroderma; morphea; immunohistochemistry



Author: Nina Troskot - et al. -

Source: http://hrcak.srce.hr/



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