Intraplaque Stretch in Carotid Atherosclerotic Plaque – an Effective Biomechanical Predictor for Subsequent Cerebrovascular Ischemic EventsReport as inadecuate




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Background

Stretch is a mechanical parameter, which has been proposed previously to affect the biological activities in different tissues. This study explored its utility in determining plaque vulnerability.

Methods

One hundred and six patients with mild to moderate carotid stenosis were recruited in this study 53 symptomatic and 53 asymptomatic. High resolution, multi-sequence magnetic resonance MR imaging was performed to delineate various plaque components. Finite element method was used to predict high stretch concentration within the plaque.

Results

During a two-year follow-up, 11 patients in symptomatic group and 3 in asymptomatic group experienced recurrent cerebrovascular events. Plaque stretch at systole and stretch variation during one cardiac cycle was greater in symptomatic group than those in the asymptomatic. Within the symptomatic group, a similar trend was observed in patients with recurrent events compared to those without.

Conclusion

Plaques with high stretch concentration and large stretch variation are associated with increased risk of future cerebrovascular events.



Author: Zhongzhao Teng , Umar Sadat , Wenkai Wang, Nasim S. Bahaei, Shengyong Chen, Victoria E. Young, Martin J. Graves, Jonathan H. Gill

Source: http://plos.srce.hr/



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