Eight Functional Polymorphisms in the Estrogen Receptor 1 Gene and Endometrial Cancer Risk: A Meta-AnalysisReport as inadecuate




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Background and Objective

Emerging evidence indicates that common functional polymorphisms in the estrogen receptor 1 ESR1 gene may have an impact on an individual’s susceptibility to endometrial cancer, but individually published results are inconclusive. The aim of this meta-analysis is to derive a more precise estimation of the associations between eight polymorphisms in the ESR1 gene and endometrial cancer risk.

Methods

A literature search of PubMed, Embase, Web of Science and China Biology Medicine CBM databases was conducted on publications published before November 1st, 2012. Crude odds ratios ORs with 95% confidence intervals CIs were calculated. Statistical analyses were performed using the STATA 12.0 software.

Results

Thirteen case-control studies were included with a total of 7,649 endometrial cancer cases and 16,855 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results indicated that PvuII C>T polymorphism was associated with an increased risk of endometrial cancer, especially among Caucasian populations. There were also significant associations between rs3020314 C>T polymorphism and an increased risk of endometrial cancer. Furthermore, rs2234670 S-L polymorphism may decrease the risk of endometrial cancer. However, no statistically significant associations were found in XbaI A>G, Codon 325 C>G, Codon 243 C>T, VNTR S-L and rs2046210 G>A polymorphisms.

Conclusion

The current meta-analysis suggests that PvuII C>T and rs3020314 C>T polymorphisms may be risk factors for endometrial cancer, especially among Caucasian populations.



Author: Xin Zhou , Yang Gu, Ding-ning Wang, Sha Ni, Jun Yan

Source: http://plos.srce.hr/



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