Epidemiology of Streptococcus pneumoniae Serogroup 6 Isolates from IPD in Children and Adults in GermanyReport as inadecuate




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This study presents serogroup 6 isolates from invasive pneumococcal disease IPD before and after the recommendation for childhood pneumococcal conjugate vaccination in Germany July 2006. A total of 19,299 children: 3508, adults: 15,791 isolates were serotyped. Serogroup 6 isolates accounted for 9.5% children and 6.7% adults, respectively. 548 isolates had serotype 6A, 558 had serotype 6B, 285 had serotype 6C, and 4 had serotype 6D. Among children, serotype 6B was most prevalent 7.5% of isolates before vaccination, followed by 6A and 6C. After the 7-valent pneumococcal conjugate vaccine PCV7, the prevalence of serotype 6B significantly decreased p = 0.040, a pattern which continued in the higher-valent PCV period PCV10, PCV13. Serotype 6A prevalence showed a slight increase directly after the start of PCV7 vaccination, followed by a decrease which continued throughout the PCV10-13 period. Serotype 6C prevalence remained low. Serotype 6D was not found among IPD isolates from children. Among adults, prevalence of both 6A and 6B decreased, with 6B reaching statistical significance p = 0.045 and 6A showing a small increase in 2011–2012. Serotype 6C prevalence was 1.5% or lower before vaccination, but increased post-vaccination to 3.6% in 2011-12 p = 0.031. Four serotype 6D isolates were found post-PCV7 childhood vaccination, and two post-PCV10-13. Antibiotic resistance was found mainly in serotype 6B; serotype 6A showed lower resistance rates. Serotype 6C isolates only showed resistance among adults; serotype 6D isolates showed no resistance. Multilocus sequence typing showed that sequence type ST 1692 was the most prevalent serotype 6C clone. Thirty-two other STs were found among serotype 6C isolates, of which 12 have not been previously reported. The four serotype 6D isolates had ST 948, ST 2185 and two new STs: 8422 and 8442. Two serogroup 6 isolates could not be assigned to a serotype, but had STs common to serogroup 6.



Author: Mark van der Linden , Nadine Winkel, Sharon Küntzel, Aron Farkas, Stephanie Russo Perniciaro, Ralf René Reinert, Matthias Imöh

Source: http://plos.srce.hr/



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