Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine Sigma Receptor Agonist in Rats with Neonatal Ventral Hippocampal LesionReport as inadecuate




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The effect of chronic administration of the sigma agonist: 1,3-di-o-tolyl-guanidineDTG, in neonatal ventral hippocampal lesioned nVHL rats, on theimmobility by clamping and dorsal immobility, were investigated. The nVHLincreases the duration of immobility by clamping, but does not affect theduration of the dorsal immobility. We found that DTG augments the duration ofthe dorsal immobility in the unlesioned rats, but does not modify the durationof immobility induced by clamping the neck. DTG also counteracts the increasein the duration of the immobility by clamping produced by nVHL. However, theincrease in the duration of the dorsal immobility produced by DTG iscounteracted by nVHL. These results are discussed with respect to thedifferential effect on the two immobility responses tested, suggesting thatthey are different forms of immobility mediated by different mechanismsalthough they behaviorally share common characteristics.

KEYWORDS

Immobility Response, Sigma Receptor, DTG, Schizophrenia, Neonatal Ventral Hippocampal Lesion

Cite this paper

Jaramillo, B. , Cruz, F. , Vargas, G. , Morales, O. , Flores, G. , Zamudio, S. and Garcés-Ramírez, L. 2014 Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine Sigma Receptor Agonist in Rats with Neonatal Ventral Hippocampal Lesion. Pharmacology & Pharmacy, 5, 681-690. doi: 10.4236-pp.2014.57078.





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