In Vivo 9.4T MRI and 1H MRS for Evaluation of Brain Structural and Metabolic Changes in the Ts65Dn Mouse Model for Down SyndromeReport as inadecuate




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In the present study we investigated structural and metabolic modifications of the brain in the Ts65Dn mouse model of Down syndromeDSusing both in vivo magnetic resonance imagingMRIand proton magnetic resonance spectroscopyMRS. MRI was performed for further texture analysis and changes in texture parameters, including mean grey levels, contrast and homogeneity, and they were found in Ts65Dn compared to diploid littermates 2n. These phenotypic changes were different in the hippocampus and cerebellum, since in Ts65Dn mean grey levels increased in the cerebellum and decreased in the hippocampus. In addition, proton NMR spectra revealed differences in metabolite ratios. Levels of N-acetylaspartateNAAand glutamateGlu, were lower compared to total creatine levels CX, in the Ts65Dn brain. However, the most striking finding was an increase in the concentration of myo-inositolInsand cholineChoin the hippocampus, whereas the Ins concentration was reduced in the cerebellum. Overall, these data illustrate that MRI and MRS are valuable assesment tools sufficiently sensitive to detect associated changes in different brain areas, thus providing new insight into the causative role of dosage-sensitive genes in the Ts65Dn DS mouse model.

KEYWORDS

Magnetic Resonance Imaging, Texture Analysis, 1H Magnetic Resonance Spectroscopy, Down Syndrome, Mouse Model

Cite this paper

Même, S. , Joudiou, N. , Yousfi, N. , Szeremeta, F. , Lopes-Pereira, P. , Beloeil, J. , Herault, Y. and Même, W. 2014 In Vivo 9.4T MRI and 1H MRS for Evaluation of Brain Structural and Metabolic Changes in the Ts65Dn Mouse Model for Down Syndrome. World Journal of Neuroscience, 4, 152-163. doi: 10.4236-wjns.2014.42018.





Author: S. Même, N. Joudiou, N. Yousfi, F. Szeremeta, P. Lopes-Pereira, J. C. Beloeil, Y. Herault, W. Même

Source: http://www.scirp.org/



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