IL28B Polymorphism Correlates with Active Hepatitis in Patients with HBeAg-Negative Chronic Hepatitis BReport as inadecuate




IL28B Polymorphism Correlates with Active Hepatitis in Patients with HBeAg-Negative Chronic Hepatitis B - Download this document for free, or read online. Document in PDF available to download.

Background and Aims

The clinical relevance of single nucleotide polymorphisms SNPs near the IL28B gene is controversial in patients with hepatitis B virus HBV infection. This study aimed to investigate the role of viral and host factors, including IL28B genotypes, in the natural course of chronic hepatitis B CHB.

Methods

The study enrolled consecutive 115 treatment-naive CHB patients. HBV viral loads, genotypes, precore and basal core promotor mutations, serum hepatitis B surface antigen HBsAg and interferon-gamma inducible protein 10 IP-10 levels as well as four SNPs of IL28B were determined. Serial alanine transaminase ALT levels in the previous one year before enrollment at an interval of three months were recorded. Factors associated with active hepatitis, defined as persistent ALT >2× upper limit of normal ULN or a peak ALT level >5× ULN, were evaluated.

Results

The prevalence of rs8105790 TT, rs12979860 CC, rs8099917 TT, and rs10853728 CC genotypes were 88.3%, 87.4%, 88.4% and 70.9%, respectively. In HBeAg-positive patients n = 48, HBV viral load correlated with active hepatitis, while in HBeAg-negative patients n = 67, rs10853728 CC genotype p = 0.032 and a trend of higher IP-10 levels p = 0.092 were associated with active hepatitis. In multivariate analysis, high viral load HBV DNA >108 IU-mL, p = 0.042, odds ratio = 3.946 was significantly associated with HBeAg-positive hepatitis, whereas rs10853728 CC genotype p = 0.019, odds ratio = 3.927 was the only independent factor associated with active hepatitis in HBeAg-negative population.

Conclusions

HBV viral load and IL28B rs10853728 CC genotype correlated with hepatitis activity in HBeAg-positive and HBeAg-negative CHB, respectively. Both viral and host factors play roles in disease activity during different phases of CHB.



Author: I-Cheng Lee, Chen-Hao Lin, Yi-Hsiang Huang , Teh-Ia Huo, Chien-Wei Su, Ming-Chih Hou, Hui-Chun Huang, Kuei-Chuan Lee, Che-Chang C

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents