Primary Anorectal Melanomas Interest of Targeting C-KIT in Two Cases from a Series of 11 PatientsReport as inadecuate




Primary Anorectal Melanomas Interest of Targeting C-KIT in Two Cases from a Series of 11 Patients - Download this document for free, or read online. Document in PDF available to download.

Background: The anorectallocation of melanomas is extremely rare 1% - 3%of all melanomas, and the prognosis remains poor because of the aggressivenessand the high metastatic potential of those tumors. The discovery that the KIToncogene may be aberrantly activated in a subset of patients with anorectalmelanoma creates a realm of possibility for the development of targetedmolecular therapy. Aim: to show the epidemiologic, clinico-radiological,histological features and treatment management especially in patients withover-expression of C-KIT treated by Imatinib. Methods: It is a retrospectivestudy conducted in the department of medical oncology at Hassan II UniversityHospital between January 2007 and January 2012, including all patients withhistologically proven melanoma of the anorectal area. Results: 11 cases werecollected, with slight female predominance. Nine patients were metastatic atthe moment of diagnosis, and only two with local stage, but evolution wasmarked by local and distant recurrence less than 12 months after abdo-minoperinealresection. First line of chemotherapy was based mainly on paclitaxel,carboplatine and dacarbazine. Response was modest with only 3 partialresponses, 4 patients with disease stability, and 4 patients with diseaseprogression. Two patients, with over expression of C-KIT, received Imatinib assecond line of treatment with significant improvement of symptoms and radiologicalresponse reaching 50%. Seven patients died with a median survival of 11 monthsfrom diagnosis to the date of death. Conclusion: Primary anorectal melanomasare very rare, with high aggressiveness and poor prognosis. Treatmentmanagement is still a big challenge given to the modest efficacy ofconventional chemotherapy. Better understanding of carcinogenesis and signalingpathways will allow development of new targeted therapies.

KEYWORDS

Melanoma; Anorectal Area; Surgery; Chemotherapy; C-KIT; Imatinib

Cite this paper

Oualla, K. , Mellas, N. , El’mrabet, F. , Arifi, S. , Amarti, A. , Taleb, K. , Tizniti, S. and Elmesbahi, O. 2014 Primary Anorectal Melanomas Interest of Targeting C-KIT in Two Cases from a Series of 11 Patients. Journal of Cancer Therapy, 5, 225-230. doi: 10.4236-jct.2014.53029.





Author: Karima Oualla, Nawfel Mellas, Fatimazahra El’mrabet, Samia Arifi, Afaf Amarti, Khalid Ait Taleb, Siham Tizniti, Omar Elmesbahi

Source: http://www.scirp.org/



DOWNLOAD PDF




Related documents