Hand-Held Tidal Breathing Nasal Nitric Oxide Measurement – A Promising Targeted Case-Finding Tool for the Diagnosis of Primary Ciliary DyskinesiaReport as inadecuate




Hand-Held Tidal Breathing Nasal Nitric Oxide Measurement – A Promising Targeted Case-Finding Tool for the Diagnosis of Primary Ciliary Dyskinesia - Download this document for free, or read online. Document in PDF available to download.

Background

Nasal nitric oxide nNO measurement is an established first line test in the work-up for primary ciliary dyskinesia PCD. Tidal breathing nNO TB-nNO measurements require minimal cooperation and are potentially useful even in young children. Hand-held NO devices are becoming increasingly widespread for asthma management. Therefore, we chose to assess whether hand-held TB-nNO measurements reliably discriminate between PCD, and Healthy Subjects HS and included Cystic Fibrosis CF patients as a disease control group known to have intermediate nNO levels.

Methods

In this cross sectional, single centre, single occasion, proof-of-concept study in children and adults with PCD and CF, and in HS we compared feasibility, success rates, discriminatory capacity, repeatability and agreement between a hand-held electrochemical device equipped with a nNO software application sampling at flow rates 2 ml-s or 5 ml-s, and two stationary chemiluminescence devices, applying both tidal breathing and velum closure techniques.

Results

Measurements were done in 16 PCD patients, 21 patients with CF and 20 HS aged between 3.8 and 60.9 years. Hand-held TB-nNO showed high success rate 96.5–100% vs. velum closure nNO techniques 70.2–89.5%. Hand-held TB-nNO sampling at flow rate 5 ml-s showed equally high discriminative power PCD vs. HS p<0.0001 and PCD vs. CF p<0.0001 and reaching close to 100% sensitivity and specificity, superior repeatability CV% = 10% and equal limits of agreement compared to TB-nNO by stationary devices and even compared to velum closure sampling.

Conclusion

Hand-held TB-nNO discriminates significantly between PCD, CF and HS and shows promising potential as a widespread targeted case-finding tool for PCD, although further studies are warranted before implementation.



Author: June Kehlet Marthin, Kim Gjerum Nielsen

Source: http://plos.srce.hr/



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