Antioxidants as effective remedies at hepatotoxic action of carbon tetrachlorideReport as inadecuate




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The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract GSE, α-tocopherol α-T. As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.

KEYWORDS

CCl4; GSE; α-Tocopherol; Ultrastructural Changes; Intoxicated Hepatocytes; Electron Microscopy

Cite this paper

Hovnanyan, K. , Mamikonyan, V. , Margaryan, A. , Sargsyan, K. , Hovnanyan, M. , Karagyozyan, M. and Karageuzyan, K. 2014 Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride. Journal of Biophysical Chemistry, 5, 1-4. doi: 10.4236-jbpc.2014.51001.





Author: Karlen Hovnanyan, Vardan Mamikonyan, Anahit Margaryan, Kristine Sargsyan, Margarita Hovnanyan, Maria Karagyozyan, Konstantin Kara

Source: http://www.scirp.org/



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