The genome of herpes simplex virus type 1 is prone to form short repeat sequencesReport as inadecuate




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Herein, we reporta very high content of simple sequencerepeats SSRs covering 66.12% of the herpessimplex virus type 1 HSV-1 genome when a low threshold is adopted todefine SSRs, indicating that repeat sequence is a very important character ofthe HSV-1 genome. The repeats with two iterations account for 68.33% of the total repeats. In reality,the genome of HSV-1 is prone to form shorter repeat sequences. For mono-, di- and trinucleotiderepeats, the repeat numbers decreased with the increase of repeats iterations, implicating that theformation tendencyof SSRs might be from low iterations to high iterations. The high iterationsSSRs might have subjectedto strong selected pressure and survived to perform different functions. Theanalysis suggested that the repeats formation may be an essential evolutionary driving force for the HSV-1genome, and the results might be helpful for studying the genome structure,repeats genesis and genome evolution of HSV-1.

KEYWORDS

Simple Sequence Repeat; HSV-1 Genome; Microsatellite; SSR

Cite this paper

Zhao, X. , Wu, X. , Qin, L. , Tan, Z. , Li, S. , Ouyang, Q. and Tian, Y. 2013 The genome of herpes simplex virus type 1 is prone to form short repeat sequences. Journal of Biosciences and Medicines, 1, 26-30. doi: 10.4236-jbm.2013.13006.





Author: Xiangyan Zhao, Xiaolong Wu, Lv Qin, Zhongyang Tan, Shifang Li, Qingjian Ouyang, You Tian

Source: http://www.scirp.org/



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