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Introduction: The early cancer of gallbladder is an entity which is not wellrecognized currently. It is a cancer which does not extend beyond themuscularis layer of the gallbladder and it is characterized in almost of casesby the absence of lymph node and visceral invasion. Patients and Method: We have conducted this retrospective study ofall our cases of early gallbladder cancer treated in our surgical unit. We havestudied these through clinical, morphological, therapeutical and evolutionaryaspects. Results: Of 202 gallbladdercarcinoma, 33 cancers were classified as early cancer. 25 were females and 8were males. The mean age was 56.4 years 41 - 70 years.All patients were free of gallbladder cancer symptoms and all except one hadnormal CEA and CA19.9. 2 patients had synchronous tumors one colonic cancerand one rectal cancer. For 16 patients, the diagnosis wasdone by ultrasonography and 17 by histological examination of the specimenremoved for biliary lithiasis. 8 patients had PT1a tumor confined only tomucosa and 25 had PT1b tumor tumor infiltration of the muscular layer. For19 patients who benefited from extensive lymphadenectomy, onlyone 5.3% had lymph node infiltration. 16 patients had a simplecholecystectomy and in two cases, the cholecystectomy was associated with bileduct resection. 17 patients had hepatectomy with extensive lymphadenectomy. 2 patientshad a simultaneous right colectomy and abdominoperineal resection and anotherone benefited from choledocal cyst resection. 3 patients benefited from stoneremoval from bile duct and two had tumor removal from bile duct ruptured tumorin the bile duct. 1 patient 3.7% died in postoperative course hospital mortality.In the follow-up period, 4 patients died from intercurrent causes. Two patientspresented a recurrence at 14 and 36 months and died respectively at 19 and 42 months.One patient presented a bile duct cancer at 66 months. She died at78 months after palliative treatment. Currently, 22 patients66.7% are still alive without recurrence with mean and median survival of 53and 31 months. Conclusion: Earlygallbladder cancer is an entity which must be known by the radiologistand the surgeon. Recognized on time and well treated, early gallbladder cancercan be cured and its prognosis is excellent.

KEYWORDS

Early Cancer; Gallbladder Cancer; Ultrasonography; Expert Radiologist; Surgical Treatment

Cite this paper

B. Salah and A. Larbi -Early Gallbladder Cancer: Clinical, Morphological, Therapeutic and Evolutionary Aspects,- Surgical Science, Vol. 4 No. 11, 2013, pp. 486-493. doi: 10.4236-ss.2013.411095.





Author: Berkane Salah, Abid Larbi

Source: http://www.scirp.org/



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