Serum Vitamin D in Patients with Chronic Obstructive Lung Disease Does Not Correlate with Mortality – Results from a 10-Year Prospective Cohort StudyReport as inadecuate




Serum Vitamin D in Patients with Chronic Obstructive Lung Disease Does Not Correlate with Mortality – Results from a 10-Year Prospective Cohort Study - Download this document for free, or read online. Document in PDF available to download.

Background

Recent studies have found vitamin D 25-OHD deficiency and insufficiency to be common among patients with COPD. Serum level of 25-OHD seems to correlate to pulmonary function, COPD disease staging, and increased susceptibility to respiratory infections. We wanted to investigate whether vitamin D deficiency or insufficiency was associated with mortality rate in patients suffering from advanced COPD.

Methods

25-OHD serum levels were measured in 462 patients suffering from moderate to very severe COPD. Patients were stratified into three groups according to serum levels of 25-OHD. Outcome measure was mortality in a 10 year follow-up period. Kaplan-Meier curves KM were plotted and mortality hazard ratios HR were calculated using Cox Proportional Hazard regression Cox PH.

Results

Serum 25-OHD deficiency and insufficiency were prevalent. We were unable to demonstrate any association between baseline serum levels of 25-OHD and mortality rate. We found an association between mortality and age HR 1.05 CI 95%: 1.03–1.06, Charlson score HR 1.49 CI 95%: 1.06–2.09, increasing neutrophil count HR 1.05 CI 95%: 1.02–1.09, severe HR 1.41 CI 95%: 1.06–1.86-very severe COPD HR 2.19 CI 95%: 1.58–3.02 and a smoking history of more than 40 pack years HR 1.27 CI 95%: 1.02–1.70.

Conclusions

Serum level of 25-OHD does not seem to be associated with mortality rate, suggesting no or only a minor role of 25-OHD in disease progression in patients with moderate to very severe COPD.



Author: Dennis Back Holmgaard , Lone Hagens Mygind, Ingrid Louise Titlestad, Hanne Madsen, Palle Bach Nielsen Fruekilde, Svend Stenvang P

Source: http://plos.srce.hr/



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