Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving ConceptReport as inadecuate




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Background

Idiopathic pulmonary fibrosis IPF has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells EPCs are considered to possess lung tissue repair and vascular remodeling properties.

Objectives

The study aimed to assess early EPCs levels and EPCs endogenous vascular endothelial growth factor VEGF expression in IPF. In order to examine alterations in the mobilization of EPCs from the bone marrow we measured plasma VEGF.

Main Results

Twenty-three patients with IPF and fifteen healthy subjects were included. The number of early EPCs colonies was markedly reduced in IPF patients vs controls 6.00±6.49 vs 49.68±16.73, respectively, p<0.001. EPCs were further decreased in patients presenting systolic pulmonary arterial pressure sPAP≥35 mmHg. The number of colonies per well correlated negatively with PA-aO2 r =  −0.750, p<0.001. Additionally, VEGF mRNA levels were significantly increased in IPF patients. There were no differences observed in VEGF plasma levels in IPF patients when compared to controls.

Conclusions

The current data suggest that inadequate levels of early EPCs may potentially contribute to suppressed repair and recovery of the damaged pulmonary endothelium and thereby may drive the sequence of events in profibrogenic direction. Increased VEGFmRNA levels in the clinical context of IPF may represent a compensatory mechanism to overcome reduced EPCs levels.



Author: Foteini Malli, Angela Koutsokera, Efrosini Paraskeva, Epaminondas Zakynthinos, Maria Papagianni, Dimosthenes Makris, Irene Tsilio

Source: http://plos.srce.hr/



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