Botulinum Toxin A in the Treatment of Oropharyngeal or Esophageal DysphagiaReport as inadecuate




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Objectives: In this retrospective analysis, we exploredthe effect of botulinum toxin A BTA injection to treat oropharyngeal dysphagia or esophagealdysfunction caused by diseases of the upper UES and lower LES esophagealsphincter. Methods: In total, 48 patients 17 patients with UESdisorders, and 31 patients with LES dysfunction; mean age 64 years weretreated between 1996 and 2007 in our hospital. Comorbid diseases as well asmaintenance medication were documented to evaluate the overall health status of ourpatients. The mean duration of symptoms, the number of pre-treatments and the specificationof dysphagia were considered. Results: One month after injection, the responserates were 73.3% UES group and 76.6% LES group. Most patients in the UESgroup received 30-40 units BTA Botox? whereas most patients in the LES groupwere treated with 100 units BTA. In cases of re-injection, 50% of patients inthe UES group experienced an escalation of dosage up to 75 units, whereasthe other 50% received the same dosage. The dosages in the LES group weremostly kept constant. Conclusion: Comparing the two groups withesophageal dysfunction of fundamentally different etiologies UES-LES, adiscrepancy in the level of symptom relief, onset and a longer cessation ofclinical benefit were observed in the LES group. In this analysis, we were ableto show that injection of BTA is an effective and safe treatment for disordersof the UES and LES.



KEYWORDS

Botulinum Toxin; Dysphagia; Upper Esophageal Sphincter; Lower Esophageal Sphincter

Cite this paper

C. Beutner, K. Bartsch, H. Schwörer, R. Laskawi and S. Rohrbach -Botulinum Toxin A in the Treatment of Oropharyngeal or Esophageal Dysphagia,- International Journal of Otolaryngology and Head & Neck Surgery, Vol. 2 No. 6, 2013, pp. 253-258. doi: 10.4236-ijohns.2013.26053.





Author: Caroline Beutner, Katharina Bartsch, Harald Schwörer, Rainer Laskawi, Saskia Rohrbach

Source: http://www.scirp.org/



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